Man Dies After H5N2 Bird Flu Infection. Here’s How It Differs From H5N1

A brand new pressure of chicken flu, H5N2, was simply recognized in Mexico Metropolis, following the loss of life of a 59-year-old man. The pressure, completely different from the H5N1 chicken flu that has contaminated three dairy farm staff within the U.S., has not been beforehand seen in folks. A part of the concern is that the person had been bedridden at dwelling and had no identified publicity to birds or animals.

The person did have underlying diabetes and power kidney failure, each of which make folks extra vulnerable to infections. He grew to become in poor health on April 17 with fever, shortness of breath and diarrhea. He died on April 24. None of his contacts have had optimistic assessments for flu A up to now. Nevertheless, El Common reported that “12 contacts (seven symptomatic and 5 asymptomatic) have been recognized close to the affected person’s residence” and that serology is pending. H5N2 has been identified to be circulating in birds within the space.

It’s complicated to maintain all of the names of the completely different flu varieties straight—H5N1, H5N2, chicken flu, swine flu, flu A, flu B and extra.

The three fundamental forms of flu, A, B and C, are named after core proteins. We have now annual outbreaks of influenza A, which is probably the most severe. Influenza A H1N1 brought on the lethal 1918 outbreak. Flu B is normally much less extreme and causes infections each few years. Flu C hasn’t brought on epidemics.

The “H” and “N” within the names check with floor proteins, hemagglutinin and neuraminidase, which assist the virus keep on with and invade the cells. Typically, the strains mutate and swap genetic materials, making it extra infective. This occurred when H1N1 and H2N2 mixed and mutated in birds, leading to a “chicken flu” that might now infect folks. This resulted within the 1957 influenza pandemic in Asia from H2N2, a novel (new to people) pressure.

Strains are additionally divided into extremely pathogenic avian influenza or low pathogenic. The largest concern in latest months has been HPAI H5N1.

The very best illustration of the connection between completely different flu strains in folks and animals is that by David McCandless.

H5N1 is the pressure decimating some poultry flocks and dairy herds. We all know it has unfold to trigger sickness in a couple of folks, however we don’t know the extent as a result of solely restricted and insufficient testing is being finished.

“We’re making the identical errors right this moment that we made with COVID. And what do I imply by that? We’re not testing to actually see how many individuals have been uncovered and obtained asymptomatically contaminated,” Deborah Birx, former Covid-19 response coordinator, advised CNN. “We could possibly be pool testing each dairy employee. I do imagine that there’s undetected instances in people, as a result of we’re as soon as once more solely monitoring folks with signs. After we did that with COVID, the virus unfold all through the Northeast undetected.”

Influenza specialist Andy Pekosz, Ph.D. echoed this, saying, “Proper now, there needs to be intensive, maybe weekly testing of all dairy farm staff coupled with elevated availability and coaching of staff to make use of protecting gear.”

He added, “My understanding is that these applications have capability, however as a result of they’re voluntary, they want settlement from farmers and farmer staff to take part. CDC can’t mandate testing, however they’ll present it. I feel elevated testing and protecting gear will be finished in a manner that’s minimally disruptive to a dairy farm operation, however clearly there may be reticence to participate in these voluntary applications.”

With this Mexican affected person, the consensus amongst consultants is that that is doubtless an remoted “spillover” case, and the danger to the final inhabitants could be very low. Nevertheless, there may be rising concern that this or the H5N1 virus within the U.S. will mutate and grow to be extra infectious. H5 viruses are reportedly extra prone to infect folks than different strains.

There was an ongoing outbreak of H5N1 in Asia with a a lot greater mortality. Pekosz stated there was “higher documentation of the case-fatality price there,” given their greater numbers. “The massive variety of instances in Asia are primarily on account of elevated human-poultry contact in that a part of the world. In case you restrict issues like stay chicken markets and supply poultry farm staff with some primary protecting gear, you may drastically restrict human H5N1 instances anyplace, however notably in Southeast Asia.”

The H5N1 virus is more and more present in numerous wild animals, most lately cats and mice. Dr. Rick Shiny, virologist, pandemic knowledgeable and former head of the U.S. Biomedical Superior Analysis and Growth Authority, advised The Telegraph, “This brings the virus nearer to human houses. It will increase the danger of direct publicity and an infection.” It should make any management efforts far harder because the mice can rapidly unfold an infection. Rodents are infamous for inflicting epidemics, from the Black Demise (bubonic plague), to Lassa fever in Africa, to Hantavirus within the Southwest U.S.

One other criticism of present management efforts is that there’s a delay of weeks in making information public, and genetic sequencing to see similarities between strains can be not being made public. Shiny famous, “Must urgently see sequences to know if it was totally avian virus, or attainable reassortant with human H3N2 virus.”

Individuals are additionally calling for vaccinations to be provided for dairy staff, which is being began in Finland.

For now, your greatest security precautions are to put on masks and goggles if within the neighborhood of cows being milked and to keep away from uncooked dairy merchandise. I’d additionally suggest avoiding 4H membership reveals or county festivals. In case you can’t resist going, it could be most secure to put on a masks and goggles, given what we presently find out about transmission.